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KMID : 0861220120140020076
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Journal of the Korean Society Clinical Neurophysiology
2012 Volume.14 No. 2 p.76 ~ p.79
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Statin-Induced Autoimmune Necrotizing Myopathy Responsive to Immunosuppressive Therapy
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Park Yeong-Eun
Seo Jae-Deuk
Kim Dae-Seong
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Abstract
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Statin is commonly used for lowering cholesterols and can be myotoxic to cause drug-induced necrotizing myopathy. Statininduced myopathy ranges from asymptomatic hyperCKemia to lethal rhabdomyolysis but is usually reversed by withdrawal of causative drugs. The patient in this study presented with statin-induced necrotizing myopathy, which was finally improved with immunosuppressive therapy, but not just with drug withdrawal. Since statin can induce myopathy through autoimmune processes, we should consider using immunomodulating agents in cases with statin-induced myopathy, which is refractory to drug withdrawal.
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KEYWORD
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Statin, Autoimmune necrotizing myopathy, Immunosuppression
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